ABSTRACT
Aim. To assess the prevalence of non-alcoholic fatty liver disease (NAFLD) using the liver obesity index - FLI (Fatty Liver Index), and to study its associations with socio-demographic indicators and behavioral risk factors for NAFLD. Material and methods. The data from the multicenter ESSE-RF study (Epidemiology of cardiovascular diseases in the regions of the Russian Federation) - samples from the unorganized male and female population aged 25-64 years were used. 5,161 respondents were included, of which 2,275 (44,1%) were men. To assess the prevalence of NAFLD, the liver obesity index FLI was used, calculated according to the formula by Bedogni G, et al. (2006). A high FLI index =60 was considered a predictor of liver steatosis. Results. High FLI =60 was detected in 38,5% of men and 26,6% of women. Multivariate analysis of associations of high FLI index in men and women showed a strong relationship with age: men - odds ratio (OR) 5,01, 95% confidence interval (CI): 3,82-6,59 (p<0,0001) and women - OR 8,58, 95% CI: 6,39-11,64 (p<0,0001), living in rural areas: men - OR 1,32, 95% CI: 1,06-1,63 (p=0,011) and women - OR 1,4, 95% CI: 1,15-1,71 (p=0,001). The FLI index >=60 was significantly associated with low physical activity (p=0,001) in men and current smoking in women (p=0,013). Conclusion. A high FLI index >=60 is most common among men, significantly associated with age, living in rural areas, currently smoking women, and low physical activity men. Higher education, in relation to FLI >=60, had a protective effect on women. Copyright © 2022 Vserossiiskoe Obshchestvo Kardiologov. All rights reserved.
ABSTRACT
Objective. To assess the dynamics of seroprevalence of anti-SARS-CoV-2 antibodies in the population of non-vaccinated people. Materials and methods. During two months of the last quarter of 2020 (before the start of mass vaccination against the coronavirus infection), we analyzed the dynamics of the level of total anti-SARS-CoV-2 IgG and level of virus-neutralizing IgG (anti-RBD/S1) in 806 unvaccinated people without clinical signs of the disease Results. Upon first examination, 16.0% of participants were found to have positive total anti-SARS-CoV-2 IgG, while 82.6% were negative and 1.4% had indeterminate result. During two months of the pandemic, seroprevalence increased by 23.7% (from 16.0% to 39.7%). The proportion of people with an indeterminate result remained the same (1.4%). The proportion of patients with asymptomatic COVID-19 who were initially IgG-positive but became negative in two months was 5.4%. Some individuals with positive total anti-SARS-CoV-2 IgG were found to have non-reactive anti-RBD antibodies that did not ensure neutralization of coronavirus (17.8% upon first and 10.6% upon second examination). © 2021, Dynasty Publishing House. All rights reserved.